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How Menstrual Cycles Shape Women’s Memory and Brain

A new study in Nature Mental Health by Rachel Zsido and Julia Sacher of the Max Planck Institute for Human Cognitive and Brain Sciences and the University Clinic in Leipzig

Research reveals a notable interplay between fluctuating ovarian hormones during the menstrual cycle and structural adaptations within women’s brains, particularly in regions vital for cognitive function. Utilizing a meticulous approach, researchers tapped into 7 Tesla MRI and blood sampling across six menstrual cycle points to observe how estradiol and progesterone influenced medial temporal lobe and hippocampal regions, pivotal areas for episodic memory and spatial cognition.

By establishing that such brain areas remodel in sync with hormonal oscillations, a door opens toward understanding how these natural fluctuations might impact mental health and cognitive resilience.

The study underscores the imperative of exploring the scarcely researched realm of the female brain, shedding light on its dynamic, rhythmic transformations, and the implications these have for long-term brain health and susceptibility to disorders.

Key Facts:

  1. Dynamic Hormone Impact: The study pinpoints how fluctuations in ovarian hormones, specifically estradiol and progesterone, influence structural changes in crucial brain regions during reproductive years.
  2. Focus on Underexplored Territory: Despite the significant impact of sex steroid hormones on cognitive functions, less than 0.5% of neuroimaging literature addresses transitional hormonal phases like the menstrual cycle, hormonal contraceptive use, pregnancy, and menopause.
  3. Link to Mental Health: The research intends to pave the way for understanding how the rhythmic alterations in brain structure might correlate with risks or resilience towards mental health issues, such as depression and Alzheimer’s, particularly in women.

Central learning and memory hubs change in response to sex hormones. A new study in Nature Mental Health by Rachel Zsido and Julia Sacher of the Max Planck Institute for Human Cognitive and Brain Sciences and the University Clinic in Leipzig, Germany, links rhythmic oscillations in ovarian hormone levels in women during the menstrual cycle to changes in brain structure.

Read the whole article here.

  Quelle: (30.10.2023 - LW)
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