The seminars are a mix of state-of-the-art lectures, case presentations, workshops, and in many instances, hands-on training. They are offered to highly qualified English-speaking physicians from countries in transition and are by invitation only.

First-time applicants must be under the age of 40, fluent in English, have either completed their specialization or are in the final phase, and plan to pursue a professional career in their home countries. Each OMI seminar is limited to a maximum of 36 participants. This allows for intense interaction during lectures, discussions, case presentations, and hands-on training sessions. The OMI seminars are taught by physicians from leading American and European institutions who donate their time and expertise. The selection of participants is competitive and based on merit. Fellowships cover travel, tuition, a set of teaching materials, and full board.

All OMI fellows must contribute academically by presenting an interesting case study. The best cases are subsequently published electronically on the OMI Case Library. Each OMI fellow takes a test at the beginning and end of the seminar. This measures what they have learned. Fellows in the top 50% are eligible to participate in the OMI observership program and apply for additional seminars. The OMI seminar content is accessible through the OMI Handbook Online, which is a free e-learning source for the OMI alumni.